Super Health Sprays use a highly effective instant-mist technology. Absorption of nutrients with Super Health Sprays occurs when  you spray a solution in your mouth  – the nutrients’ molecules are taken up into the capillaries in the mouth. In other words, these molecules penetrate the membrane ( Buccal Mucosa), which lines the inside of the mouth. Once across this membrane nutrients enter the blood vessels and then get distributed via the blood circulation. This is a rapid process, taking place in the space of a few seconds. Then all nutrients are carried throughout the body bypassing the digestive sytem. As the spray delivers the dose in fine particulates or droplets, the lag time for the nutrients to be available for the site of the absorption is reduced.

Good quality of supplements is associated with their ability to  be dissolved and absorbed.

Dr Srinivasan

About Bioavailability

Facts about Buccal Mucosa

  1. Mucosa of the buccal cavity was found to be the most convenient and easily accessible site for the delivery of therapeutic agents for both local and systemic delivery.
  2. The mucosa has a rich blood supply and it is relatively permeable.
  3. Blood vessels drain directly into the jugular vein; due to its particular features, it has been of increasing interest to researchers as an alternative site of drug administration.
  4. Direct access to the systemic circulation through the internal jugular vein bypasses nutrients from the hepatic first pass metabolism leading to high bioavailability.
  5. The oral cavity is an attractive site for nutrients delivery due to ease of administration and avoidance of possible drug degradation in gastrointestinal tract and first-pass metabolism.
  6. Studies by Dr Squier and co-workers revealed that the permeability of water through the buccal mucosa was approximately 10 times higher, whilst in floor of the mouth the permeability was approximately 20 times higher than skin.

P. Pozzilli, S. Manfrini, F. Costanza, G. Coppolino, M.G. Cavallo, E. Fioriti, P. Modi, Biokinetics of buccal spray insulin in patients with type 1 diabetes, Metabol. Clin. Exp. 54 (2005) 930-934.
Srinivasan, V.S. 2001. Bioavailability of Nutrients: A Practical Approach to In Vitro Demonstration of the Availability of Nutrients in Multivitamin-Mineral Combination Products. J. Nutr. 131:1349S-1350S.
Hoag, S.W., Ramachandruni, H. and Shargraw, R.F. 1997. Failure of Prescription Prenatal Vitamin Products to Meet USP Standards for Folic Acid Dissolution. J. Am. Pharm Assoc. 37:397-400.

Super Health Sprays

  • All  solutions in sprays  have been formulated with great care in mind.
  • No artificial flavours or colours added to  their solutions.
  • No sugar, starch, wheat, soy, gluten, eggs, salt, or dairy.
  • We use Xylitol (which is known for cavity protection and it is diabetic-safe).
  • The flavors are natural mints or fruits.
  • All our vitamin sprays are suitable for vegetarians.

High Bioavailability

Nutrients in Super Health sprays can be absorbed in both sublingual (placed under the tongue) and buccal (placed inside the cheek) areas where they go through the thin mucous membrane directly into the bloodstream. While being a fine mist spray,  each Super Health spray is also an emulsion, meaning that vitamins and other ingredients are fully mixed with the water base. This again helps the absorption and bioavailability within the body.

Precision of Dosage

Each Super Health Spray gives a precise, metered dose of nutrients with every pump. This ensures that a user receives the correct dose each time. No more trouble with counting the number of spoonfuls or drops of liquid/powder.

Safety

Our sprays are save and free from any side effects – unlike tables, the sprays contain no fillers. This reduces the chance of an allergic or nauseous reaction to nearly zero. In addition, the metal container of the sprays protects their ingredients from oxidation ( light and air) that allows to keep their solution potent and guarantees a much longer shelf life.

Buccal and Sublingual Absorption

Oral transmucosal delivery (especially buccal and sublingual absorption) is an interesting and simple concept with massive repercussions throughout the health industry. Drug delivery based on buccal and sublingual routes is a highly active research field and in the next few years we can expect more and more drugs and supplements to be developed for delivery by buccal absorption. The main key factor is that transmucosal delivery allows the bypass of significant barriers imposed for the peroral administration, such as hepatic first pass metabolism and drug degradation within the gastrointestinal (GI) tract.

Case Study: Insulin

Pharmacokinetic studies of buccal insulin spray in patients with Type I diabetes revealed that insulin, delivered through a novel insulin buccal spray, easily passed through the buccal mucosa. It proved that administration of insulin in spray form can be an effective therapeutic alternative to current medication systems for treating diabetes (references 1- 2).

Case Study: Nitroglycerin

Nitroglycerin is perhaps the best-known example. In fact, the only way that nitroglycerin is administered is by “oral absorption.” (The first recognition of the ability of a substance to cross the oral mucosa was reported by Braunton in 1877).   On top, there are  thousands of published research papers on oral absorption (both buccal and sublingual) of vitamins, minerals and drugs.

P. Pozzilli, S. Manfrini, F. Costanza, G. Coppolino, M.G. Cavallo, E. Fioriti, P. Modi, Biokinetics of buccal spray insulin in patients with type 1 diabetes, Metabol. Clin. Exp. 54 (2005) 930-934.
H. Xu, K. Huang, Y. Zhu, Q. Gao, Q. Wu, W. Tian, X. Sheng, Z. Chen, Z. Gao, Hypoglycaemic effect of a novel insulin buccal formulation on rabbits, Pharmacol. Res. 46 (2002) 459-467.
Srinivasan, V.S. 2001. Bioavailability of Nutrients: A Practical Approach to In Vitro Demonstration of the Availability of Nutrients in Multivitamin-Mineral Combination Products. J. Nutr. 131:1349S-1350S.
Hoag, S.W., Ramachandruni, H. and Shargraw, R.F. 1997. Failure of Prescription Prenatal Vitamin Products to Meet USP Standards for Folic Acid Dissolution. J. Am. Pharm Assoc. 37:397-400.
Stamatakis, M.K. and Meyer-Stout, P.J. 1999. Disintegration Performance of Renal Multivitamin Supplements. J.Renal Nutr. 9:78-83.